Malaria Parasite Plasmodium falciparum Erythrocyte Binding Antigen 140

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Introduction

In 2010, malaria caused over 650,000 deaths.[1] While this disease is both preventable and curable, many of those that live in areas where the disease is endemic do not have access to such resources. Although there is a vaccine currently undergoing clinical trials, results are not expected until 2014.[1] The most recent vaccine research has focused on understanding a group of proteins in the erythrocyte-binding ligand (EBL) family. These proteins, which are found in the Plasmodium species, facilitate entry into erythrocytes during malarial infection by creating tight junctions between the host erythrocytes and parasite membranes. [2]

Your Heading Here (maybe something like 'Structure')

Structure of HMG-CoA reductase (PDB entry 1dq8)

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References

  1. ↑ 1.0 1.1 http://www.who.int/mediacentre/factsheets/fs094/en/index.html
  2. ↑ Lin DH, Malpede BM, Batchelor JD, Tolia NH. Crystal and Solution Structures of Plasmodium falciparum Erythrocyte-binding Antigen 140 Reveal Determinants of Receptor Specificity during Erythrocyte Invasion. J Biol Chem. 2012 Oct 26;287(44):36830-6. doi: 10.1074/jbc.M112.409276. Epub 2012, Sep 18. PMID:22989878 doi:10.1074/jbc.M112.409276

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Emily Lum, Alexander Berchansky

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