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Pyruvate dehydrogenase (E1) along with two other enzymes make up the multienzyme complex pyruvate dehydrogenase. Dihydrolipoyl transacetylase (E2) and dihydrolipoyl dehydrogenase (E3) are the other two main components of the complex. These enzymes work together to synthesize acetyl Co-A from pyruvate before entering the Kreb's cycle. The pyruvate dehydrogenase complex acts to link glycolysis to the citric acid cycle.
Pyruvate dehydrogenase consists of a combination of beta strands and alpha helices. this is the site of between three residues of pyruvate dehydrogenase.
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