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Tubulin

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Image:1z5w.png

Crystal Structure of Tubulin 1z5w

Template:STRUCTURE 1z5w

Tubulin (TUB) is a constituent of microtubules in eukaryotes. Microtubules are assembled from dimers of α-tubulin (TUBA) and β-tubulin (TUBB) bound to GTP. γ-tubulin (TUBG) is part of the nucleation of microtubules. Human TUB contains several numbered subtypes. FtsZ (Filamenting temperature-sensitive mutant Z) is a prokaryotic homologue of TUB. The images at the left and at the right correspond to one representative Tubulin, i.e. the crystal structure of Tubulin (1z5w).

1 3D Structures of Tubulin

3D Structures of Tubulin

Tubulin

α-tubulin

2bto – PdTUBA+thioredoxin 1 – Prosthecobacter dejongeii

α-tubulin + β-tubulin

3hkb, 3hkc, 3hkd, 3hke, 3n2g, 3n2k – sTUBA+sTUBB+stathmin-like protein B3 – sheep
3ryc, 3ryf, 3ryh, 3ryi - sTUBA+sTUBB+stathmin-4
2wbe – cTUBA1D+cTUBB2B+kinesin+AMPPNP – cow
3dco - cTUBA+cTUBB+kinesin-like NOD
1tvk - cTUBA+cTUBB+GDP+GTP+Epothilone A – electron crystallography
3iz0 - cTUBA+cTUBB+hNDC80/SPC25+hNUF2/SPC24 – electron microscopy
3edl - cTUBA1D+cTUBB2B+kinesin motor domain
2xrp - cTUBA1D+cTUBB2B+doublecortin
3du7, 3e22, 1z2b, 1sa0, 1sa1 – cTUBA1C+cTUBB2B+stathmin-like protein B3
1ffx - cTUBA+cTUBB+stathmin-like protein B3
1jff - cTUBA+cTUBB
2p4n - hTUBA+hTUBB+kinesin heavy chain
2hxf - pTUBA+pTUBB+kinesin-like KIF1A+AMPPNP – pig
2hxh - pTUBA+pTUBB+kinesin-like KIF1A+ADP
1ia0 - pTUBA+pTUBB+kinesin-like KIF1A+ATP
1tub - pTUBA+pTUBB – electron diffraction
2btq – PdTUBA+PdTUBB

γ-tubulin

3cb2 – hTUBG1+GDP
1z5v - hTUBG1+GTPgS
1z5w - hTUBG1+GTP

FtsZ

2rhh, 2rhj – BsFtsZ+SO4 – Bacillus subtilis
2rhl - BsFtsZ+GDP
2rho - BsFtsZ+GDP+GTP-gamma-S
2vxy, 2vam – BsFtsZ
2ve8 – PaFtsZ gamma domain – Pseudomonas aeruginosa
2ve9 - PaFtsZ gamma domain+DNA
2vaw – PaFtsZ+GDP
1ofu - PaFtsZ+SULA
2r75 - AaFtsZ+8-morpholino-GTP – Aquifex aeolicus
2r6r - AaFtsZ
2q1x, 1rq2 - MtFtsZ+citrate – Mycobacterium tuberculosis
2q1y, 1rlu - MtFtsZ+GTP-gamma-S
1rq7 - MtFtsZ+GDP
2vap – MjFtsZ+GDP – Methancaldococcus jannaschii
1w58 - MjFtsZ+GMPCPP
1w59, 1fsz – MjFtsZ
1w5a - MjFtsZ+MgGTP
1w5b - MjFtsZ+GTP
1w5e, 1w5f – MjFtsZ (mutant)