Urokinase
From Proteopedia
Urokinase (UK) is a serine protease whose principal substrate is plasminogen – the inactive zymogen of plasmin. UK consists of 3 domains: ligand-binding domain and kringle and growth factor domains. Prourokinase (PUK) is the inactive zymogen of UK which becomes active by proteolytic cleavage.
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3D Structures of urokinase
2i9a - hUK Hc N terminal
Urokinase heavy chain complex with inhibitors
1fv9 – hUK B chain (mutant) + benzimidazole derivative – human
1f5k - hUK B chain (mutant) + benzamidine derivative
1f5l - hUK B chain (mutant) + amiloride derivative
1f92, 1sc8, 1vj9, 1vja, 2o8t, 2o8u, 2o8w - hUK B chain (mutant) + inhibitor
1owd, 1owe, 1owh, 1owi, 1owj, 1owk, 1sqa, 1sqo, 1u6q - hUK B chain + naphthamidine inhibitor
1ejn - hUK B chain (mutant) + urea derivative inhibitor
3kpg – hUK Hc C terminal (mutant) + benzoic acid derivative
3khv - hUK Hc C terminal (mutant) + methanol derivative
3mwi - hUK Hc C terminal (mutant) + amidine derivative
3ox7, 3oy5, 3oy6 - hUK Hc C terminal (mutant) + peptide inhibitor
3kid, 3mhw - hUK Hc C terminal (mutant) + aminobenzothiazole derivative
2vin, 2vio, 2vip, 2viq, 2viv, 2viw - hUK B chain catalytic domain (mutant) + mexiletine derivative
2vnt, 2r2w - hUK B chain catalytic domain + guanidine derivative
1w0z, 1w10, 1w11, 1w12, 1w13, 1w14 - hUK B chain catalytic domain + alanineamide derivative
2nwn - hUK Hc C terminal + cyclic peptide
3m61 - hUK Hc C terminal (mutant) + cyclic peptide
Urokinase light+heavy chain complex with inhibitors
1lmw – hUK A+B catalytic domain + EGRCMK
1c5w, 1c5x, 1c5y, 1c5z - hUK A+B chain catalytic domain + carboxamidine derivative
1gi7, 1gi8, 1gi9, 1gj7, 1gj8, 1gj9, 1gja, 1gjb, 1gjc, 1gjd - hUK A+B chain catalytic domain (mutant) + carboxamidine derivative
1o3p, 1o5a, 1o5b, 1o5c - hUK A+B chain catalytic domain (mutant) + benzenolate derivative
3ig6 – hUK A+B chain catalytic domain + inhibitor
Urokinase complex with protein
2fd6 – hUK Hc N terminal + antibody + UK receptor
3bt1, 3bt2 - hUK Hc N terminal + vitronectin + UK receptor
3laq - hUK Hc N terminal + UK receptor
3pb1 - hUK Hc C terminal (mutant) + UK inhibitor
2i9b - hUK Hc N terminal + UK receptor (mutant)
