User:Sruti Aiyaswamy/Sandbox 1

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Contents 1 Introduction 2 MR1 is MHC Class I Related 3 Structure of MR1-antigen Complex 4 MR1-restricted MAIT Activation 5 Biological Significance 6 References

Introduction

The MHC class I-like molecule, MR1, is an antigen presenting protein that specifically activates mucosal-associated invariant T (MAIT) cells.^[1] It has been found that microbial vitamin B metabolites serve as MR1 ligands that activate the MAIT cells.

MR1 is MHC Class I Related

spinqualitylabelsall models MHC Class I in complex with peptide Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Where does this lead?

Finally relate how MHC structure/function is similar to MR1. Explain chains, b2m, folding.

Structure of MR1-antigen Complex

spinqualitylabelsall models Structure of MR1 in complex with b2m and 6-formyl Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Where does this lead?

MR1-restricted MAIT Activation

spinqualitylabelsall models MAIT Cell Receptor Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Biological Significance

References

1. ↑ Ochs HD, Oukka M, Torgerson TR. TH17 cells and regulatory T cells in primary immunodeficiency diseases. J Allergy Clin Immunol. 2009 May;123(5):977-83; quiz 984-5. PMID:19410687 doi:10.1016/j.jaci.2009.03.030