SP3.4-TCR-HLA-DQ8-α-1-gliadin complex
From Proteopedia
Introduction
Celiac disease is a disorder that damages the lining of the small intestine when dietary gluten such as wheat barley and rye is consumed. When a person with celiac disease ingests gluten an immune response cascades and damages the microvilli of the small intestine. This damage prevents nutrient absorption and causes malnourishment. (pubMEd)
Celiac disease is typically a predisposed genetic disorder in individuals that express a human leukocyte antigen HLA-DQ2 and/or HLA-DQ8 molecules. Gluten peptidases bind to these HLA-DQ8 and HLA-DQ2 molecules and cause a T cell mediated response. Specifically, TRBV9*01 is the T-cell responsible for the recognition of the HLA-DQ8-∝-I-gliadin. (paper)
Anything in this section will appear adjacent to the 3D structure and will be scrollable. is a viral encoded enzyme that converts the viral single-stranded RNA genome into a double-stranded DNA provirus that is integrated into the host chromosome in the host cell's nucleus. The process of converting viral ssRNA into dsDNA that can incorporate into the host chromosome is called retrotranscription, and is characteristic of all retroviruses. HIV-1 reverse transcriptase is encoded by the human immunodeficiency virus, well known as the etiological agent of acquired immune deficiency syndrome (AIDS).
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