Acid phosphatase
From Proteopedia
Acid phosphatase (ACP, EC number 3.1.3.2) is an enzyme which removes phosphate from other molecules during digestion. It catalyzes the conversion of orthophosphoric monoester and H2O to alcohol and phosphoric acid. The enzyme is most effective in acidic environment. Prostatic ACP (PSAP) is produced by the prostate. It is found in increased amounts in patients who have prostate cancer. Purple ACP (PAP) contain a dinuclear Fe center and their oxidized for in solution maintains a purple color. Histidine ACP (HAP) catalyze the transfer of phosphoryl group using an active-site histidine.
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3D Structures of acid phosphatase
Update November 2011
1qfx – ACP – Aspergillus niger
1dkm, 1dkn – EcACP (mutant) + Hg – Escherichia coli
1dkl – EcACP
1n8n – EcACP-B + Au3
1n9k, 3cz4 - EcACP-B + Mg
1rmt - EcACP-B + adenosine + Mg
1rmq - EcACP-B + Co + Os
1dko - EcACP (mutant) + Hg + WO4
2heg - EcACP-B + Mg + aspartate-BeF3
2hf7 - EcACP-B + Mg + AlF3
1d2t - EbACP – Escherichia blattae
1iw8 - EbACP (mutant)
1eoi – EbACP + MoO4
2akc - StACP-A + WO4 - Salmonella typhimurium
2p4u – mACP1 + phosphate – mouse
2gfh – mACP acetylneuraminic
2i33 – BaACP-C + Mg – Bacillus anthracis
2i34 - BaACP-C + Mg + WO4
3pct – ACP-C – Pasteurella multocida
3et4, 3et5 – HiACP – Haemophilus influenzae
Acid phosphatase complex with phosphate derivative
2b82 - EcACP-B + adenosine + Mg + phosphate
2b8j - EcACP-B + adenosine + Mg + spermine + Au3 + phosphate
1rmy - EcACP-B + Mg + deoxycytidine + phosphate
2g1a - EcACP-B + Mg + phosphonic acid derivative
1dkp, 1dkq - EcACP (mutant) + Hg + inositol hexakisphosphate
2a96 – StACP-A + phosphate
3ocu – HiACP (mutant) + nicotineamide mononucleotide
3ocv, 3ocw, 3ocx, 3sf0 - HiACP (mutant) + AMP
3ocy - HiACP + phosphate
3ocz - HiACP + AMP derivative
Histidine acid phosphatase
2d1g – FtHAP-A + VO4 – Francisella tularensis
2ipb - FtHAP-A (mutant)
3it0 - FtHAP-A + phosphate
3it1 - FtHAP-A + tartrate
3it2 - FtHAP-A
3it3 - FtHAP-A (mutant) + 3’- AMP
Tyrosine acid phosphatase
1bvh – bYAP – bovine – NMR
1pnt, 1xww – bYAP
1z12 – bYAP + VO4
1z13 – bYAP + MoO4
Prostate acid phosphatase
1rpa – rPSAP + tartaric acid – rat
1rpt – rPSAP + VO4
2hpa – hPSAP + propyl tartramic acid – human
1cvi – hPSAP
2l3h, 2l77, 2l79 – hPSAP residues 248-286 - NMR
1nd5, 1nd6 – hPSAP + inhibitor
Purple acid phosphatase
1kbp, 2qfp, 2qfr – PvPAP + Fe + Zn – Phaseolus vulgaris
3kbp - PvPAP + Fe + Zn + WO4
4kbp - PvPAP + Fe + Zn + phosphate
2qfr - PvPAP + Fe + Zn + sulfate
1qhw - rPAP + Fe + Zn
1qfc - rPAP + Fe + phosphate
1war – hPAP + Fe + phosphate
2bq8 - hPAP + Fe + Zn
1ute – PAP + μ-oxo-diiron – pig
1xzw - PAP + Fe + Mn + phosphate – sweet potato
