Cholesterol esterase (ChoE) also named bile-acid activated lipase catalyzes the hydrolytic cleavage of cholesterol, other sterol esters and triglycerides. Deficiency of this enzyme causes Wolman’s disease and cholesteryl ester storage disease.
3D structures of cholesterol esterase
1akn – bChoE – bovine
2bce – bChoE (mutant)
1jmy – hChoE - human
1f6w – hChoE catalytic domain (mutant)
Cholesterol esterase complex with bile acids
1cle – CcChoE + cholesteryl linoleate – Candida cylindracea
1llf – CcChoE + tricosanoic acid
1aql – bChoE + taurocholate
