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spinqualitylabelsall models PDB ID 1s8o Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
X-ray crystal structure of hsEH: assymetric unit, 1s8o
Ligands:
Gene:	EPHX2 (Homo sapiens)
Activity:	Hydrolase, with EC number and 3.3.2.10 3.3.2.9 and 3.3.2.10
Related:	1vj5
Structural annotation: Resources: InterPro : Ipr011945, Ipr005834, Ipr006402, Ipr003089, Ipr005833, Ipr000639, Ipr000073 Pfam : PF00702, PF00561 SCOP : d1s8oa2, d1s8oa1 UniProt : P34913
Functional annotation: Cellular component: peroxisome soluble fraction cytosol cytoplasm Biological process: oxygen and reactive oxygen species metabolic process cellular calcium ion homeostasis inflammatory response response to toxin metabolic process positive regulation of vasodilation xenobiotic metabolic process drug metabolic process aromatic compound metabolic process aromatic compound catabolic process regulation of blood pressure Molecular function: magnesium ion binding catalytic activity epoxide hydrolase activity metal ion binding hydrolase activity protein homodimerization activity
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

Contents 1 Overview 2 Structure 3 Mechanism 4 Inhibitors 5 External ressources 6 References 7 Proteopedia Page Contributors and Editors

Overview

Structure

spinqualitylabelsall models X-ray crystal structure of hsEH Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

The Human soluble Epoxide hydrolase is a homodimer. Each subunit has , linked by a proline-rich section.

Mechanism

Inhibitors

External ressources

References

Proteopedia Page Contributors and Editors

DUTREUX Fabien, BONHOURE Anna