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2xh5

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Revision as of 19:26, 7 January 2013 by OCA (Talk | contribs)
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Image:2xh5.png

Template:STRUCTURE 2xh5

STRUCTURE OF 4-(4-TERT-BUTYLBENZYL)-1-(7H-PYRROLO(2,3-D) PYRIMIDIN-4-YL)PIPERIDIN-4-AMINE BOUND TO PKB

Template:ABSTRACT PUBMED 20151677

About this Structure

2xh5 is a 2 chain structure with sequence from Homo sapiens. This structure supersedes the now removed PDB entry 2x37. Full crystallographic information is available from OCA.

Reference

  • McHardy T, Caldwell JJ, Cheung KM, Hunter LJ, Taylor K, Rowlands M, Ruddle R, Henley A, de Haven Brandon A, Valenti M, Davies TG, Fazal L, Seavers L, Raynaud FI, Eccles SA, Aherne GW, Garrett MD, Collins I. Discovery of 4-Amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamides As Selective, Orally Active Inhibitors of Protein Kinase B (Akt). J Med Chem. 2010 Feb 12. PMID:20151677 doi:10.1021/jm901788j

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