1h4w
From Proteopedia
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STRUCTURE OF HUMAN TRYPSIN IV (BRAIN TRYPSIN)
Overview
Severe neurodegradative brain diseases, like Alzheimer, are tightly linked, with proteolytic activity in the human brain. Proteinases expressed in the, brain, such as human trypsin IV, are likely to be involved in the, pathomechanism of these diseases. The observation of amyloid formed in the, brain of transgenic mice expressing human trypsin IV supports this, hypothesis. Human trypsin IV is also resistant towards all studied, naturally occurring polypeptide inhibitors. It has been postulated that, the substitution of Gly193 to arginine is responsible for this inhibitor, resistance. Here we report the X-ray structure of human trypsin IV in, complex with the inhibitor benzamidine at 1.7 A resolution. The overall, fold of human trypsin IV is similar to human trypsin I, with a root-mean, ... [(full description)]
About this Structure
1H4W is a [Single protein] structure of sequence from [Homo sapiens] with CA and BEN as [ligands]. Active as [Trypsin], with EC number [3.4.21.4]. Structure known Active Site: CAT. Full crystallographic information is available from [OCA].
Reference
Crystal structure reveals basis for the inhibitor resistance of human brain trypsin., Katona G, Berglund GI, Hajdu J, Graf L, Szilagyi L, J Mol Biol. 2002 Feb 1;315(5):1209-18. PMID:11827488
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