1ygo
From Proteopedia
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Solution Structure of the pelle Death Domain
Overview
The interaction between the death domains (DDs) of Tube and the protein kinase Pelle is an important component of the Toll pathway. Published crystallographic data suggests that the Pelle-Tube DD interface is plastic and implies that in addition to the two predominant Pelle-Tube interfaces, a third interaction is possible. We present the NMR solution structure of the isolated death domain of Pelle and a study of the interaction between the DDs of Pelle and Tube. Our data suggests the solution structure of the isolated Pelle DD is similar to that of Pelle DD in complex with Tube. Additionally, they suggest that the plasticity observed in the crystal structure may not be relevant in the functioning death domain complex.
About this Structure
1YGO is a Single protein structure of sequence from Drosophila melanogaster. Active as Non-specific serine/threonine protein kinase, with EC number 2.7.11.1 Full crystallographic information is available from OCA.
Reference
Solution structure of the isolated Pelle death domain., Moncrieffe MC, Stott KM, Gay NJ, FEBS Lett. 2005 Jul 18;579(18):3920-6. PMID:16004997
Page seeded by OCA on Thu Feb 21 16:05:08 2008
