1yk7
From Proteopedia
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Cathepsin K complexed with a cyanopyrrolidine inhibitor
Contents |
Overview
Starting from a PDE IV inhibitor hit derived from high throughput screening of the compound collection, a key pyrrolidine cyanamide pharmacophore was identified. Modifications of the pyrrolidine ring produced enhancements in cathepsin K inhibition. An X-ray co-crystal structure of a cyanamide with cathepsin K confirmed the mode of inhibition.
Disease
Known disease associated with this structure: Pycnodysostosis OMIM:[601105]
About this Structure
1YK7 is a Single protein structure of sequence from Homo sapiens with as ligand. Active as Cathepsin K, with EC number 3.4.22.38 Full crystallographic information is available from OCA.
Reference
Novel and potent cyclic cyanamide-based cathepsin K inhibitors., Deaton DN, Hassell AM, McFadyen RB, Miller AB, Miller LR, Shewchuk LM, Tavares FX, Willard DH Jr, Wright LL, Bioorg Med Chem Lett. 2005 Apr 1;15(7):1815-9. PMID:15780613
Page seeded by OCA on Thu Feb 21 16:06:08 2008
Categories: Cathepsin K | Homo sapiens | Single protein | Barrett, D G. | Deaton, D N. | Hassell, A M. | McFadyen, R B. | Miller, A B. | Miller, L R. | Shewchuk, L M. | Tavares, F X. | Willard, D H. | Wright, L L. | NBL | Cathepsin | Catk | Cysteine | Protease
