1yks
From Proteopedia
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Crystal structure of yellow fever virus NS3 helicase
Overview
Yellow fever virus (YFV), a member of the Flavivirus genus, has a plus-sense RNA genome encoding a single polyprotein. Viral protein NS3 includes a protease and a helicase that are essential to virus replication and to RNA capping. The 1.8-A crystal structure of the helicase region of the YFV NS3 protein includes residues 187 to 623. Two familiar helicase domains bind nucleotide in a triphosphate pocket without base recognition, providing a site for nonspecific hydrolysis of nucleoside triphosphates and RNA triphosphate. The third, C-terminal domain has a unique structure and is proposed to function in RNA and protein recognition. The organization of the three domains indicates that cleavage of the viral polyprotein NS3-NS4A junction occurs in trans.
About this Structure
1YKS is a Single protein structure of sequence from Yellow fever virus. Active as Flavivirin, with EC number 3.4.21.91 Full crystallographic information is available from OCA.
Reference
Structure of the Flavivirus helicase: implications for catalytic activity, protein interactions, and proteolytic processing., Wu J, Bera AK, Kuhn RJ, Smith JL, J Virol. 2005 Aug;79(16):10268-77. PMID:16051820
Page seeded by OCA on Thu Feb 21 16:06:21 2008
Categories: Flavivirin | Single protein | Yellow fever virus | Bera, A K. | Kuhn, R J. | Smith, J L. | Wu, J. | Atpase | Dead-box | Flavivirus | Helicase | Rtpase
