1o7b

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Image:1o7b.png

Template:STRUCTURE 1o7b

REFINED SOLUTION STRUCTURE OF THE HUMAN TSG-6 LINK MODULE

Template:ABSTRACT PUBMED 12972412

About this Structure

1o7b is a 1 chain structure with sequence from Homo sapiens. This structure supersedes the now removed PDB entry 1tsg. Full experimental information is available from OCA.

Reference

  • Blundell CD, Mahoney DJ, Almond A, DeAngelis PL, Kahmann JD, Teriete P, Pickford AR, Campbell ID, Day AJ. The link module from ovulation- and inflammation-associated protein TSG-6 changes conformation on hyaluronan binding. J Biol Chem. 2003 Dec 5;278(49):49261-70. Epub 2003 Sep 11. PMID:12972412 doi:http://dx.doi.org/10.1074/jbc.M309623200
  • Getting SJ, Mahoney DJ, Cao T, Rugg MS, Fries E, Milner CM, Perretti M, Day AJ. The link module from human TSG-6 inhibits neutrophil migration in a hyaluronan- and inter-alpha -inhibitor-independent manner. J Biol Chem. 2002 Dec 27;277(52):51068-76. Epub 2002 Oct 24. PMID:12401803 doi:10.1074/jbc.M205121200
  • Lesley J, English NM, Gal I, Mikecz K, Day AJ, Hyman R. Hyaluronan binding properties of a CD44 chimera containing the link module of TSG-6. J Biol Chem. 2002 Jul 19;277(29):26600-8. Epub 2002 May 13. PMID:12011075 doi:10.1074/jbc.M201068200
  • Mahoney DJ, Blundell CD, Day AJ. Mapping the hyaluronan-binding site on the link module from human tumor necrosis factor-stimulated gene-6 by site-directed mutagenesis. J Biol Chem. 2001 Jun 22;276(25):22764-71. Epub 2001 Apr 3. PMID:11287417 doi:10.1074/jbc.M100666200
  • Kahmann JD, O'Brien R, Werner JM, Heinegard D, Ladbury JE, Campbell ID, Day AJ. Localization and characterization of the hyaluronan-binding site on the link module from human TSG-6. Structure. 2000 Jul 15;8(7):763-74. PMID:10903951
  • Kahmann JD, Koruth R, Day AJ. Method for quantitative refolding of the link module from human TSG-6. Protein Expr Purif. 1997 Apr;9(3):315-8. PMID:9126602 doi:10.1006/prep.1996.0694
  • Day AJ, Aplin RT, Willis AC. Overexpression, purification, and refolding of link module from human TSG-6 in Escherichia coli: effect of temperature, media, and mutagenesis on lysine misincorporation at arginine AGA codons. Protein Expr Purif. 1996 Aug;8(1):1-16. PMID:8812829 doi:10.1006/prep.1996.0068

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