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1z5l
From Proteopedia
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Structure of a highly potent short-chain galactosyl ceramide agonist bound to CD1D
Overview
Natural killer T cells express a conserved, semi-invariant alphabeta T cell receptor that has specificity for self glycosphingolipids and microbial cell wall alpha-glycuronosylceramide antigens presented by CD1d molecules. Here we report the crystal structure of CD1d in complex with a short-chain synthetic variant of alpha-galactosylceramide at a resolution of 2.2 A. This structure elucidates the basis for the high specificity of these microbial ligands and explains the restriction of the alpha-linkage as a unique pathogen-specific pattern-recognition motif. Comparison of the binding of altered lipid ligands to CD1d and T cell receptors suggested that the differential T helper type 1-like and T helper type 2-like properties of natural killer T cells may originate largely from differences in their 'loading' in different cell types and hence in their tissue distribution in vivo.
About this Structure
1Z5L is a Protein complex structure of sequences from Mus musculus with , and as ligands. Full crystallographic information is available from OCA.
Reference
Structure and function of a potent agonist for the semi-invariant natural killer T cell receptor., Zajonc DM, Cantu C 3rd, Mattner J, Zhou D, Savage PB, Bendelac A, Wilson IA, Teyton L, Nat Immunol. 2005 Aug;6(8):810-8. Epub 2005 Jul 10. PMID:16007091
Page seeded by OCA on Thu Feb 21 16:12:16 2008
Categories: Mus musculus | Protein complex | Bendelac, A. | Cantu, C. | Mattner, J. | Savage, P B. | Teyton, L. | Wilson, I A. | Zajonc, D M. | Zhou, D. | NAG | PBS | R16 | Ig fold | Mhc fold
