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2cl5

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Image:2cl5.png

Template:STRUCTURE 2cl5

CATECHOL-O-METHYLTRANSFERASE IN COMPLEX WITH AN INHIBITOR

Template:ABSTRACT PUBMED 16618795

About this Structure

2cl5 is a 2 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

  • Palma PN, Rodrigues ML, Archer M, Bonifacio MJ, Loureiro AI, Learmonth DA, Carrondo MA, Soares-da-Silva P. Comparative study of ortho- and meta-nitrated inhibitors of catechol-O-methyltransferase: interactions with the active site and regioselectivity of O-methylation. Mol Pharmacol. 2006 Jul;70(1):143-53. Epub 2006 Apr 17. PMID:16618795 doi:10.1124/mol.106.023119
  • Rodrigues ML, Bonifacio MJ, Soares-da-Silva P, Carrondo MA, Archer M. Crystallization and preliminary X-ray diffraction studies of a catechol-O-methyltransferase/inhibitor complex. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Jan 1;61(Pt, 1):118-20. Epub 2004 Dec 24. PMID:16508109 doi:10.1107/S1744309104031197
  • Frey D, Braun O, Briand C, Vasak M, Grutter MG. Structure of the mammalian NOS regulator dimethylarginine dimethylaminohydrolase: A basis for the design of specific inhibitors. Structure. 2006 May;14(5):901-11. PMID:16698551 doi:http://dx.doi.org/10.1016/j.str.2006.03.006

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