1hkv

From Proteopedia

proteopedia linkproteopedia link

spinqualitylabelsall models 1hkv, resolution 2.60Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

MYCOBACTERIUM DIAMINOPIMELATE DICARBOXYLASE (LYSA)

Overview

The Mycobacterium tuberculosis lysA gene encodes the enzyme, meso-diaminopimelate decarboxylase (DAPDC), a pyridoxal-5'-phosphate, (PLP)-dependent enzyme. The enzyme catalyzes the final step in the lysine, biosynthetic pathway converting meso-diaminopimelic acid (DAP) to, l-lysine. The lysA gene of M. tuberculosis H37Rv has been established as, essential for bacterial survival in immunocompromised mice, demonstrating, that de novo biosynthesis of lysine is essential for in vivo viability., Drugs targeted against DAPDC could be efficient anti-tuberculosis drugs, and the three-dimensional structure of DAPDC from M. tuberculosis, complexed with reaction product lysine and the ternary complex with PLP, and lysine in the active site has been determined. The first structure of, a DAPDC confirms ... [(full description)]

About this Structure

1HKV is a [Single protein] structure of sequence from [Mycobacterium tuberculosis] with LYS and PLP as [ligands]. Active as [Diaminopimelate decarboxylase], with EC number [4.1.1.20]. Structure known Active Site: PLA. Full crystallographic information is available from [OCA].

Reference

Crystal structure of Mycobacterium tuberculosis diaminopimelate decarboxylase, an essential enzyme in bacterial lysine biosynthesis., Gokulan K, Rupp B, Pavelka MS Jr, Jacobs WR Jr, Sacchettini JC, J Biol Chem. 2003 May 16;278(20):18588-96. Epub 2003 Mar 10. PMID:12637582

Page seeded by OCA on Tue Oct 30 15:38:01 2007