Ribosomal protein L4
From Proteopedia
Ribosomal protein L4 (RPL4 ) is one of the 34 proteins which belong to the of the prokaryotic ribosome or to the ca. 49 proteins in the large 60S subunit of the eukaryotic ribosome. It may actively participate in the catalysis of peptide bond formation. In the archaea like in Haloarcula marismortui the L4 is called L4P (RPL4P). The images at the left and at the right correspond to one representative RPL4, i.e. the crystal structure of Ribosomal protein L4 from Thermus thermophilus (2xg0, chain F).
3D Structures of Ribosomal protein L4
Update June 2012
Updated on 14/2/2013
RPL4
1dmg – RPL4 – Thermotoga maritima
L4 in 50S subunit+RNA
2xg0, 2xg2, 3kir, 3kit, 3kiw, 3kiy – TtRPL4 in 50S subunit+RNA fragments – Thermus thermophilus
2x9s, 2x9u, 3kni, 3knk, 3knm, 3kno, 2wrj, 2wrl, 2wro, 2wrr, 3hux, 3huz, 2wh2, 2wh4, 2wdi, 2wdj, 2wdl, 2wdn, 1vsp, 2v47, 2v49, 1vsa, 2hgj, 2hgq, 2hgu, 2j01, 2j03, 1yl3, 3mrz, 3ms1, 3i8f, 3i8i, 3i9c, 3i9e, 3f1f, 3f1h, 3d5b, 3d5d, 2b66, 2b9n, 2b9p, 1giy, 2y0v, 2y0x, 2y0z, 2y11, 2y13, 2y15, 2y17, 2y19, 3pyo, 3pyr, 3pyt, 3pyv, 3tve, 3tvh, 3uye, 3uyg, 3uz1, 3uz2, 3uz8, 3uz9, 3uzf, 3uzh, 3uzk, 3uzn, 4dha, 4dhc, 3v23, 3v25, 3v27, 3v29, 3v2d, 3v2f, 3zvp - TtRPL4 in 50S subunit+5S RRNA+23S RRNA
3fin - TtRPL4 in 50S subunit+5S RRNA+23S RRNA – Cryo-EM
2wwq – EcRPL4 in 50S subunit+5S RRNA+23S RRNA+mRNA+P-site tRNA – Escherichia coli
3i1n, 3i1p, 3i1r, 3i1t, 3i20, 3i22, 3e1b, 3e1d, 3df2, 3df4, 2vhn, 2qov, 2qox, 2i2t, 2i2v, 1vs6, 1vs8, 2aw4, 2awb, 3ofd, 3og0, 1vor 1vou, 1vow, 1voy, 1vp0, 1pnu, 1pny, 3r8s, 3r8t 3uos, 3uxq, 3uxr, 3sgf, 3uos - EcRPL4 in 50S subunit+5S RRNA+23S RRNA
3fik, 2gya, 2gyc, 3bbx, 1p85, 1p86, 3izt, 3izu, 3j0t, 3j0w, 3j0y, 3j11, 3j12, 3j14, 3j19 - EcRPL4 in 50S subunit+5S RRNA+23S RRNA – Cryo-EM
3kcr - EcRPL4 in 50S subunit+5S RRNA+23S RRNA+preprotein translocase
3j01 – EcRPL4 in 50S subunit+5S RRNA+23S RRNA+preprotein translocase – Cryo-EM
2rdo - EcRPL4 in 50S subunit+5S RRNA+23S RRNA+EF-G+RRF – Cryo-EM
3bbo – RPL4 in 50S subunit+5S RRNA+23S RRNA+4.8S RRNA – Cryo-EM – spinach
3iy9 – RPL4 in 50S subunit – Leishmania taretolae
2zjq, 2zjr, 1nkw - DrRPL4 in 50S subunit+5S RRNA+23S RRNA – Deinococcus radiodurans
1kqs - HmRPL4P in 50S subunit+5S RRNA+23S RRNA+CCA - Haloarcula marismortui
1jj2, 1ffk, 3cc2, 2qa4 - HmRPL4P in 50S subunit+5S RRNA+23S RRNA
3cc7, 3cce, 3ccj, 3ccl, 3ccm, 3ccq, 3ccr, 3ccs, 3ccu, 3ccv - HmRPL4P in 50S subunit+5S RRNA+23S RRNA (mutant)
3j21 – RPL4 in 50S subunit – Pyrococcus furiosus
L4 in 50S subunit + antibiotics
3dll, 2zjp, 3cf5, 1xbp, 1sm1, 1nwx, 1nwy, 3pio, 3pip - DrRPL4 in 50S subunit+5S RRNA+23S RRNA+antibiotic
3oh5, 3oh7, 3ohj, 3ohk, 3ohz, 3oi1, 3oi3, 3oi5 – TtRPL4 in 50S subunit+5S RRNA+23S RRNA+antibiotic
2qam, 2qao, 2qoz, 2qp1, 2qba, 2qbc, 3ofc, 3ofz, 3ofq, 3ofr, 1vt2, 3orb, 3oas, 3oat, 4gar, 4gau- EcRPL4 in 50S subunit+5S RRNA+23S RRNA+antibiotic
1k73, 1kc8, 1k8a, 1k9m, 1kd1, 1m1k, 3i55, 3i56, 3g4s, 3g6e, 3g71, 2qex, 3cpw,3cc4, 3cd6, 2otj, 2otl, 3cxc - HmRPL4P in 50S subunit+5S RRNA+23S RRNA+antibiotic - Halobacterium marismortui
1m90, 3cma, 3cme - HmRPL4P in 50S subunit+5S RRNA+23S RRNA+ sparsomycin+CCA-Phe-caproic acid-biotin
1jzx, 1jzy, 1jzz, 1j5a, 1k01 - DrRPL4+RPL22+RPL42+23S RRNA+antibiotic
L4 in 60S subunit
3jyw - RPL4 in 60S subunit – Thermomyces lanuginosus – Cryo-EM
2ftc - RPL4 in 60S subunit+16S RRNA - bovine
1s1i - yRPL4 in 40S ribosomal subunit+18S RRNA+elongation factor 2 – Cryo-EM – yeast
3izs – yRPL4 in 60S ribosomal subunit – Cryo-EM
3u5e, 3u5i – yRPL4 in 60S ribosomal subunit
3o58, 3o5h – yRPL4 in 60S subunit+25S RRNA+5SRRNA+5.8RRNA
2ww9, 2wwa, 2wwb – yRPL4+RPL17+RPL19+RPL15+RPL25+RPL26+RPL41+RPL45+RPL49+25S RRNA+SSH1P+SSS1+SEB2
4a1a, 4a1c, 4a1e – RPL4 in 60S subunit+5SRRNA+5.8RRNA – Tetrahymna thermophila
L4 in large + small ribosomal subunit
1ml5 - EcRPL4 in 50S ribosomal subunit+30S ribosomal subunit+THX+chain release factor 2+P-site tRNA+tRNA Phe+mRNA fragment+23S RRNA+5S RRNA+16S RRNA – EM
2zkr - RPL4 in 60S ribosomal subunit+30S ribosomal subunit+28S RRNA+5.8S RRNA – Cryo-EM - dog
L4 in 50S subunit + ribosome releasing factor (RRF)
2qbe, 2qbg, 2qbi, 2qbk, 2z4l, 2z4n - EcRPL4 in 50S subunit+5S RRNA+23S RRNA+RRF
L4 in 50S subunit + various proteins
2vhm - EcRPL4 in 50S subunit+5S RRNA+23S RRNA+PDF C-terminal helix
2j28 - EcRPL4 in 50S subunit+5S RRNA+23S RRNA+signal recognition particle – Cryo-EM
1w2b - HmRPL4P in 50S subunit+5S RRNA+23S RRNA+trigger factor N-terminal
L4 in 60S subunit + various proteins
4b6a – yRPL4 in 60S subunit +25S RRNA+5SRRNA + P0 + P1 + P2 + ARX1
