We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

1kct

From Proteopedia

Revision as of 13:36, 30 October 2007 by OCA (Talk | contribs)
Jump to: navigation, search

1kct, resolution 3.46Å

Drag the structure with the mouse to rotate

ALPHA1-ANTITRYPSIN

Overview

The crystal structure of a recombinant human alpha 1-antitrypsin, in the, uncleaved and uncomplexed state, has been determined by X-ray, crystallographic methods and refined to an R-factor of 18.4% for 8.0-3.46, A data with good stereochemistry. This structure provides the first view, at the inhibitory loop and the central beta-sheet A of the uncleaved alpha, 1-antitrypsin. The reactive loop takes a distorted helical conformation, and no pre-insertion of two residues in the reactive loop into the, beta-sheet A is observed. The present structure is largely in agreement, with the model predicted by Engh, Wright, and Huber [Prot. Eng. 3 (1990), 469-477].

About this Structure

1KCT is a [Single protein] structure of sequence from [Homo sapiens]. Structure known Active Site: P1. Full crystallographic information is available from [OCA].

Reference

Crystal structure of an uncleaved alpha 1-antitrypsin reveals the conformation of its inhibitory reactive loop., Song HK, Lee KN, Kwon KS, Yu MH, Suh SW, FEBS Lett. 1995 Dec 18;377(2):150-4. PMID:8543039

Page seeded by OCA on Tue Oct 30 15:41:02 2007

Proteopedia Page Contributors and Editors (what is this?)

OCA

Personal tools