2ajl

From Proteopedia

Revision as of 14:28, 21 February 2008 by OCA (Talk | contribs)
Jump to: navigation, search

2ajl, resolution 2.5Å

Drag the structure with the mouse to rotate

X-ray Structure of Novel Biaryl-Based Dipeptidyl peptidase IV inhibitor

Overview

The discovery, SAR, and X-ray crystal structure of novel biarylaminoacyl-(S)-2-cyano-pyrrolidines and biarylaminoacylthiazolidines as potent inhibitors of dipeptidyl peptidase IV (DPP IV) are reported.

About this Structure

2AJL is a Single protein structure of sequence from Homo sapiens with and as ligands. Active as Dipeptidyl-peptidase IV, with EC number 3.4.14.5 Full crystallographic information is available from OCA.

Reference

Discovery, SAR, and X-ray structure of novel biaryl-based dipeptidyl peptidase IV inhibitors., Qiao L, Baumann CA, Crysler CS, Ninan NS, Abad MC, Spurlino JC, Desjarlais RL, Kervinen J, Neeper MP, Bayoumy SS, Williams R, Deckman IC, Dasgupta M, Reed RL, Huebert ND, Tomczuk BE, Moriarty KJ, Bioorg Med Chem Lett. 2006 Jan 1;16(1):123-8. Epub 2005 Oct 19. PMID:16236500

Page seeded by OCA on Thu Feb 21 16:28:15 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Personal tools