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2b3e
From Proteopedia
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Crystal structure of DB819-D(CGCGAATTCGCG)2 complex.
Overview
The crystal structure of the DNA minor groove biphenyl benzimidazole diamidine ligand DB819 has been determined, bound to the DNA sequence d(CGCGAATTCGCG)(2), at a resolution of 1.36 Angstrom. Conditions for reliable in silico docking that reproduce the observed position of the ligand in the minor groove have been determined.
About this Structure
2B3E is a Protein complex structure of sequences from [1] with and as ligands. Full crystallographic information is available from OCA.
Reference
Targeting the DNA minor groove with fused ring dicationic compounds: comparison of in silico screening and a high-resolution crystal structure., Campbell NH, Evans DA, Lee MP, Parkinson GN, Neidle S, Bioorg Med Chem Lett. 2006 Jan 1;16(1):15-9. Epub 2005 Nov 2. PMID:16263285
Page seeded by OCA on Thu Feb 21 16:33:42 2008
Categories: Protein complex | Campbell, N H. | Evans, D A. | Lee, M P. | Neidle, S. | Parkinson, G N. | DBN | MG | A2t2 | Crystal structure of b-dna | Db819 | Dickerson and drew dodecamer | Dna | Dna hydration. | Dna minor | Dna minor groove-ligand complex | Dna-drug complex | Double helix | Groove binder | Hydrated magnesium | Magnesium-water complex | Minor groove | Nucleic acids
