2b4c
From Proteopedia
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Crystal structure of HIV-1 JR-FL gp120 core protein containing the third variable region (V3) complexed with CD4 and the X5 antibody
Contents |
Overview
The third variable region (V3) of the HIV-1 gp120 envelope glycoprotein is immunodominant and contains features essential for coreceptor binding. We determined the structure of V3 in the context of an HIV-1 gp120 core complexed to the CD4 receptor and to the X5 antibody at 3.5 angstrom resolution. Binding of gp120 to cell-surface CD4 would position V3 so that its coreceptor-binding tip protrudes 30 angstroms from the core toward the target cell membrane. The extended nature and antibody accessibility of V3 explain its immunodominance. Together, the results provide a structural rationale for the role of V3 in HIV entry and neutralization.
Disease
Known diseases associated with this structure: CD4 lymphocyte deficiency OMIM:[186940], Lupus erythematosus, susceptibility to OMIM:[186940]
About this Structure
2B4C is a Protein complex structure of sequences from Homo sapiens and Human immunodeficiency virus 1 with , , and as ligands. Full crystallographic information is available from OCA.
Reference
Structure of a V3-containing HIV-1 gp120 core., Huang CC, Tang M, Zhang MY, Majeed S, Montabana E, Stanfield RL, Dimitrov DS, Korber B, Sodroski J, Wilson IA, Wyatt R, Kwong PD, Science. 2005 Nov 11;310(5750):1025-8. PMID:16284180
Page seeded by OCA on Thu Feb 21 16:34:00 2008
Categories: Homo sapiens | Human immunodeficiency virus 1 | Protein complex | Dimitrov, D S. | Huang, C. | Korber, B. | Kwong, P D. | Majeed, S. | Montabana, E. | Sodroski, J. | Stanfield, R L. | Tang, M. | Wilson, I A. | Wyatt, R. | Zhang, M Y. | NAG | NDG | SO4 | XYL | Cd4 induced antibody | Gp120 | Hiv-1 | Jrfl | V3 | X5
