1o6t
From Proteopedia
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INTERNALIN (INLA,LISTERIA MONOCYTOGENES)- FUNCTIONAL DOMAIN,UNCOMPLEXED
Overview
Listeria monocytogenes, a food-borne bacterial pathogen, enters mammalian, cells by inducing its own phagocytosis. The listerial protein internalin, (InlA) mediates bacterial adhesion and invasion of epithelial cells in the, human intestine through specific interaction with its host cell receptor, E-cadherin. We present the crystal structures of the functional domain of, InlA alone and in a complex with the extracellular, N-terminal domain of, human E-cadherin (hEC1). The leucine rich repeat (LRR) domain of InlA, surrounds and specifically recognizes hEC1. Individual interactions were, probed by mutagenesis and analytical ultracentrifugation. These include, Pro16 of hEC1, a major determinant for human susceptibility to L., monocytogenes infection that is essential for intermolecular ... [(full description)]
About this Structure
1O6T is a [Single protein] structure of sequence from [Listeria monocytogenes] with MG, CA, CL, SO4, MES and MES as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Structure of internalin, a major invasion protein of Listeria monocytogenes, in complex with its human receptor E-cadherin., Schubert WD, Urbanke C, Ziehm T, Beier V, Machner MP, Domann E, Wehland J, Chakraborty T, Heinz DW, Cell. 2002 Dec 13;111(6):825-36. PMID:12526809
Page seeded by OCA on Tue Oct 30 15:44:44 2007
Categories: Listeria monocytogenes | Single protein | Beier, V. | Chakraborty, T. | Domann, E. | Heinz, D.W. | Machner, M. | Schubert, W.D. | Urbanke, C. | Wehland, J. | Ziehm, T. | CA | CL | MES | MG | SO4 | Bacterial infection | Cell adhesion | Cell-wall surface protein | Leucine rich repeat
