We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

2bhs

From Proteopedia

Revision as of 14:38, 21 February 2008 by OCA (Talk | contribs)
Jump to: navigation, search
Image:2bhs.gif

2bhs, resolution 2.67Å

Drag the structure with the mouse to rotate

CRYSTAL STRUCTURE OF CYSTEINE SYNTHASE B

Overview

The enzyme O-acetylserine sulfhydrylase participates in the biosynthesis of l-cysteine in bacteria and plants. The structure of isoenzyme B (CysM) from Escherichia coli was established in a hexagonal crystal form at 2.7 A resolution (wild-type) and in a merohedrally twinned tetragonal crystal form at 2.1 A resolution (surface mutant). Structural superpositions revealed the variations with respect to isoenzyme A (CysK) and explained the different substrate specificities. A geometric model of the reaction catalyzed by CysM is proposed. Both isoenzymes are used for the production of l-amino acid derivatives as building blocks for the synthesis of peptides and peptidomimetic drugs. Since the structure of CysM revealed a remarkable main chain variation at the active center, it constitutes a further starting point for engineering mutants with novel substrate specificities.

About this Structure

2BHS is a Single protein structure of sequence from Escherichia coli with as ligand. Active as Cysteine synthase, with EC number 2.5.1.47 Known structural/functional Site: . Full crystallographic information is available from OCA.

Reference

Structure of the O-acetylserine sulfhydrylase isoenzyme CysM from Escherichia coli., Claus MT, Zocher GE, Maier TH, Schulz GE, Biochemistry. 2005 Jun 21;44(24):8620-6. PMID:15952768

Page seeded by OCA on Thu Feb 21 16:38:01 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2bhs"
Personal tools