1o95

From Proteopedia

Revision as of 13:42, 30 October 2007 by OCA (Talk | contribs)
Jump to: navigation, search
Image:1o95.gif

1o95, resolution 3.70Å

Drag the structure with the mouse to rotate

TERNARY COMPLEX BETWEEN TRIMETHYLAMINE DEHYDROGENASE AND ELECTRON TRANSFERRING FLAVOPROTEIN

Overview

Here we report the crystal structures of a ternary electron transfer, complex showing extensive motion at the protein interface. This, physiological complex comprises the iron-sulfur flavoprotein, trimethylamine dehydrogenase and electron transferring flavoprotein (ETF), from Methylophilus methylotrophus. In addition, we report the crystal, structure of free ETF. In the complex, electron density for the FAD domain, of ETF is absent, indicating high mobility. Positions for the FAD domain, are revealed by molecular dynamics simulation, consistent with crystal, structures and kinetic data. A dual interaction of ETF with trimethylamine, dehydrogenase provides for dynamical motion at the protein interface: one, site acts as an anchor, thereby allowing the other site to sample a large, range of ... [(full description)]

About this Structure

1O95 is a [Protein complex] structure of sequences from [Methylophilus methylotrophus] with FMN, ADP, SF4 and AMP as [ligands]. Active as [Transferred entry: 1.5.8.2], with EC number [1.5.99.7]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].

Reference

Extensive conformational sampling in a ternary electron transfer complex., Leys D, Basran J, Talfournier F, Sutcliffe MJ, Scrutton NS, Nat Struct Biol. 2003 Mar;10(3):219-25. PMID:12567183

Page seeded by OCA on Tue Oct 30 15:46:56 2007

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1o95"
Personal tools