2bzf

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Image:2bzf.gif

2bzf, resolution 2.87Å

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STRUCTURAL BASIS FOR DNA BRIDGING BY BARRIER-TO-AUTOINTEGRATION FACTOR (BAF)

Contents

Overview

The ability of barrier-to-autointegration factor (BAF) to bind and bridge DNA in a sequence-independent manner is crucial for its role in retroviral integration and a variety of cellular processes. To better understand this behavior, we solved the crystal structure of BAF bound to DNA. The structure reveals that BAF bridges DNA using two pairs of helix-hairpin-helix motifs located on opposite surfaces of the BAF dimer without changing its conformation.

Disease

Known disease associated with this structure: Epilepsy, myoclonic, benign adult familial OMIM:[601068]

About this Structure

2BZF is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for DNA bridging by barrier-to-autointegration factor., Bradley CM, Ronning DR, Ghirlando R, Craigie R, Dyda F, Nat Struct Mol Biol. 2005 Oct;12(10):935-6. Epub 2005 Sep 11. PMID:16155580

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