1mem

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Template:STRUCTURE 1mem

Contents 1 Crystal structure of Cathepsin K complexed with a potent vinyl sulfone inhibitor 2 Disease 3 Function 4 About this Structure 5 See Also 6 Reference

Crystal structure of Cathepsin K complexed with a potent vinyl sulfone inhibitor

Disease

[CATK_HUMAN] Defects in CTSK are the cause of pycnodysostosis (PKND) [MIM:265800]. PKND is an autosomal recessive osteochondrodysplasia characterized by osteosclerosis and short stature.

Function

[CATK_HUMAN] Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation.

About this Structure

1mem is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

• Cathepsin

Reference

• McGrath ME, Klaus JL, Barnes MG, Bromme D. Crystal structure of human cathepsin K complexed with a potent inhibitor. Nat Struct Biol. 1997 Feb;4(2):105-9. PMID:9033587