3hkk
From Proteopedia
Contents |
Structure of human Leukotriene C4 synthase in complex with glutathione sulfonate
Template:ABSTRACT PUBMED 022217203
Disease
[LTC4S_HUMAN] Defects in LTC4S are the cause of leukotriene C4 synthase deficiency (LTC4 synthase deficiency) [MIM:246530]. LTC4 synthase deficiency is a fatal neurometabolic developmental disorder. It is associated with muscular hypotonia, psychomotor retardation, failure to thrive, and microcephaly.
Function
[LTC4S_HUMAN] Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4.
About this Structure
3hkk is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
