2z5y

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Template:STRUCTURE 2z5y

Contents 1 Crystal Structure of Human Monoamine Oxidase A (G110A) with Harmine 2 Disease 3 Function 4 About this Structure 5 See Also 6 Reference

Crystal Structure of Human Monoamine Oxidase A (G110A) with Harmine

Template:ABSTRACT PUBMED 18391214

Disease

[AOFA_HUMAN] Defects in MAOA are the cause of Brunner syndrome (BRUNS) [MIM:300615]. Brunner syndrome is a form of X-linked non-dysmorphic mild mental retardation. Male patients are affected by a syndrome of borderline mental retardation and exhibit abnormal behavior, including disturbed regulation of impulsive aggression. Obligate female carriers have normal intelligence and behavior.

Function

[AOFA_HUMAN] Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine.

About this Structure

2z5y is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

• Monoamine oxidase

Reference

• Son SY, Ma J, Kondou Y, Yoshimura M, Yamashita E, Tsukihara T. Structure of human monoamine oxidase A at 2.2-A resolution: the control of opening the entry for substrates/inhibitors. Proc Natl Acad Sci U S A. 2008 Apr 15;105(15):5739-44. Epub 2008 Apr 7. PMID:18391214