1fl7

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Template:STRUCTURE 1fl7

Contents

HUMAN FOLLICLE STIMULATING HORMONE

Template:ABSTRACT PUBMED 11222739

Disease

[FSHB_HUMAN] Defects in FSHB are a cause of isolated follicle-stimulating hormone deficiency (IFSHD) [MIM:229070]. Selective follicle-stimulating hormone deficiency is an uncommon cause of infertility, producing amenorrhea and hypogonadism in women and oligo or azoospermia with normal testosterone levels in normally virilised men.[1][2][3]

Function

[FSHB_HUMAN] Stimulates development of follicle and spermatogenesis in the reproductive organs.

About this Structure

1fl7 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  • Fox KM, Dias JA, Van Roey P. Three-dimensional structure of human follicle-stimulating hormone. Mol Endocrinol. 2001 Mar;15(3):378-89. PMID:11222739
  1. ↑ Matthews CH, Borgato S, Beck-Peccoz P, Adams M, Tone Y, Gambino G, Casagrande S, Tedeschini G, Benedetti A, Chatterjee VK. Primary amenorrhoea and infertility due to a mutation in the beta-subunit of follicle-stimulating hormone. Nat Genet. 1993 Sep;5(1):83-6. PMID:8220432 doi:http://dx.doi.org/10.1038/ng0993-83
  2. ↑ Layman LC, Lee EJ, Peak DB, Namnoum AB, Vu KV, van Lingen BL, Gray MR, McDonough PG, Reindollar RH, Jameson JL. Delayed puberty and hypogonadism caused by mutations in the follicle-stimulating hormone beta-subunit gene. N Engl J Med. 1997 Aug 28;337(9):607-11. PMID:9271483 doi:10.1056/NEJM199708283370905
  3. ↑ Matthews C, Chatterjee VK. Isolated deficiency of follicle-stimulating hormone re-revisited. N Engl J Med. 1997 Aug 28;337(9):642. PMID:9280841 doi:10.1056/NEJM199708283370918

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