3ro4

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Template:STRUCTURE 3ro4

Contents 1 X-ray Structure of Ketohexokinase in complex with an indazole compound derivative 2 Disease 3 About this Structure 4 See Also 5 Reference

X-ray Structure of Ketohexokinase in complex with an indazole compound derivative

Template:ABSTRACT PUBMED 21767952

Disease

[KHK_HUMAN] Defects in KHK are the cause of fructosuria (FRUCT) [MIM:229800]. Benign defect of intermediary metabolism.^[1][2]

About this Structure

3ro4 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

• Ketohexokinase

Reference

• Zhang X, Song F, Kuo GH, Xiang A, Gibbs AC, Abad MC, Sun W, Kuo LC, Sui Z. Optimization of a pyrazole hit from FBDD into a novel series of indazoles as ketohexokinase inhibitors. Bioorg Med Chem Lett. 2011 Aug 15;21(16):4762-7. Epub 2011 Jun 29. PMID:21767952 doi:10.1016/j.bmcl.2011.06.067

1. ↑ Trinh CH, Asipu A, Bonthron DT, Phillips SE. Structures of alternatively spliced isoforms of human ketohexokinase. Acta Crystallogr D Biol Crystallogr. 2009 Mar;65(Pt 3):201-11. Epub 2009, Feb 20. PMID:19237742 doi:S0907444908041115
2. ↑ Bonthron DT, Brady N, Donaldson IA, Steinmann B. Molecular basis of essential fructosuria: molecular cloning and mutational analysis of human ketohexokinase (fructokinase). Hum Mol Genet. 1994 Sep;3(9):1627-31. PMID:7833921