3ik5

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Template:STRUCTURE 3ik5

Contents 1 SIVmac239 Nef in complex with TCR zeta ITAM 1 polypeptide (A63-R80) 2 Disease 3 Function 4 About this Structure 5 Reference

SIVmac239 Nef in complex with TCR zeta ITAM 1 polypeptide (A63-R80)

Template:ABSTRACT PUBMED 20124696

Disease

[CD3Z_HUMAN] Defects in CD247 are the cause of immunodeficiency due to defect in CD3-zeta (CD3ZID) [MIM:610163]. An immunological deficiency characterized by T-cells impaired immune response to alloantigens, tetanus toxoid and mitogens.^[1]

Function

[CD3Z_HUMAN] Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering.

About this Structure

3ik5 is a 4 chain structure with sequence from Simian immunodeficiency virus. Full crystallographic information is available from OCA.

Reference

• Kim WM, Sigalov AB, Stern LJ. Pseudo-merohedral twinning and noncrystallographic symmetry in orthorhombic crystals of SIVmac239 Nef core domain bound to different-length TCRzeta fragments. Acta Crystallogr D Biol Crystallogr. 2010 Feb;66(Pt 2):163-75. Epub 2010 Jan 22. PMID:20124696 doi:10.1107/S090744490904880X

1. ↑ Rieux-Laucat F, Hivroz C, Lim A, Mateo V, Pellier I, Selz F, Fischer A, Le Deist F. Inherited and somatic CD3zeta mutations in a patient with T-cell deficiency. N Engl J Med. 2006 May 4;354(18):1913-21. PMID:16672702 doi:354/18/1913