3b29

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Template:STRUCTURE 3b29

Contents

Human leukotriene C4 synthase in complex with dodecyl-beta-D-selenomaltoside

Template:ABSTRACT PUBMED 22139193

Disease

[LTC4S_HUMAN] Defects in LTC4S are the cause of leukotriene C4 synthase deficiency (LTC4 synthase deficiency) [MIM:246530]. LTC4 synthase deficiency is a fatal neurometabolic developmental disorder. It is associated with muscular hypotonia, psychomotor retardation, failure to thrive, and microcephaly.

Function

[LTC4S_HUMAN] Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4.

About this Structure

3b29 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  • Saino H, Ago H, Ukita Y, Miyano M. Seleno-detergent MAD phasing of leukotriene C4 synthase in complex with dodecyl-beta-D-selenomaltoside. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Dec 1;67(Pt 12):1666-73., Epub 2011 Nov 29. PMID:22139193 doi:10.1107/S1744309111042345

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