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1kvk

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Template:STRUCTURE 1kvk

Contents

The Structure of Binary complex between a Mammalian Mevalonate Kinase and ATP: Insights into the Reaction Mechanism and Human Inherited Disease

Template:ABSTRACT PUBMED 11877411

Disease

[KIME_RAT] Note=Mutation in the mevalonate kinase gene causes mevalonicaciduria.

Function

[KIME_RAT] May be a regulatory site in cholesterol biosynthetic pathway.

About this Structure

1kvk is a 1 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

  • Fu Z, Wang M, Potter D, Miziorko HM, Kim JJ. The structure of a binary complex between a mammalian mevalonate kinase and ATP: insights into the reaction mechanism and human inherited disease. J Biol Chem. 2002 May 17;277(20):18134-42. Epub 2002 Feb 27. PMID:11877411 doi:10.1074/jbc.M200912200

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OCA

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