1l3h
From Proteopedia
Contents |
NMR structure of P41icf, a potent inhibitor of human cathepsin L
Template:ABSTRACT PUBMED 12568610
Disease
[HG2A_HUMAN] Note=A chromosomal aberration involving CD74 is found in a non-small cell lung tumor. Results in the formation of a CD74-ROS1 chimeric protein.[1]
Function
[HG2A_HUMAN] Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.
About this Structure
1l3h is a 1 chain structure. Full experimental information is available from OCA.
Reference
- Chiva C, Barthe P, Codina A, Gairi M, Molina F, Granier C, Pugniere M, Inui T, Nishio H, Nishiuchi Y, Kimura T, Sakakibara S, Albericio F, Giralt E. Synthesis and NMR structure of p41icf, a potent inhibitor of human cathepsin L. J Am Chem Soc. 2003 Feb 12;125(6):1508-17. PMID:12568610 doi:10.1021/ja0207908
- ↑ Charest A, Lane K, McMahon K, Park J, Preisinger E, Conroy H, Housman D. Fusion of FIG to the receptor tyrosine kinase ROS in a glioblastoma with an interstitial del(6)(q21q21). Genes Chromosomes Cancer. 2003 May;37(1):58-71. PMID:12661006 doi:10.1002/gcc.10207
