1qo8
From Proteopedia
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THE STRUCTURE OF THE OPEN CONFORMATION OF A FLAVOCYTOCHROME C3 FUMARATE REDUCTASE
Overview
Fumarate reductases and succinate dehydrogenases play central roles in the, metabolism of eukaryotic and prokaryotic cells. A recent medium resolution, structure of the Escherichia coli fumarate reductase (Frd) has revealed, the overall organization of the membrane-bound complex. Here we present, the first high resolution X-ray crystal structure of a water-soluble, bacterial fumarate reductase in an open conformation. This structure, reveals a mobile domain that modulates substrate access to the active site, and provides new insights into the mechanism of this widespread and, important family of FAD-containing respiratory proteins.
About this Structure
1QO8 is a [Single protein] structure of sequence from [Shewanella frigidimarina] with HEM and FAD as [ligands]. Active as [[1]], with EC number [1.3.99.1]. Full crystallographic information is available from [OCA].
Reference
Open conformation of a flavocytochrome c3 fumarate reductase., Bamford V, Dobbin PS, Richardson DJ, Hemmings AM, Nat Struct Biol. 1999 Dec;6(12):1104-7. PMID:10581549
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