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2xn7

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Template:STRUCTURE 2xn7

Contents

CRYSTAL STRUCTURE OF THYROXINE-BINDING GLOBULIN COMPLEXED WITH THYROXINE-FLUORESEIN (T405-CF)

Template:ABSTRACT PUBMED 21325280

Disease

[THBG_HUMAN] Defects in SERPINA7 are a cause of thyroxine-binding globulin deficiency (TBG deficiency) [MIM:314200]. Mutations in the SERPINA7 gene can result as a whole spectrum of deficiencies, characterized by either reduced or increased TBG levels in the serum. Patients show, respectively, reduced or elevated protein-bound iodine but are euthyroid.

Function

[THBG_HUMAN] Major thyroid hormone transport protein in serum.

About this Structure

2xn7 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  • Qi X, Loiseau F, Chan WL, Yan Y, Wei Z, Milroy LG, Myers RM, Ley SV, Read RJ, Carrell RW, Zhou A. Allosteric modulation of hormone release from thyroxine and corticosteroid binding-globulins. J Biol Chem. 2011 Feb 16. PMID:21325280 doi:10.1074/jbc.M110.171082

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