1o8t

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Template:STRUCTURE 1o8t

Contents 1 GLOBAL STRUCTURE AND DYNAMICS OF HUMAN APOLIPOPROTEIN CII IN COMPLEX WITH MICELLES: EVIDENCE FOR INCREASED MOBILITY OF THE HELIX INVOLVVED IN THE ACTIVATION OF LIPOPROTEIN LIPASE. 2 Function 3 About this Structure 4 Reference

GLOBAL STRUCTURE AND DYNAMICS OF HUMAN APOLIPOPROTEIN CII IN COMPLEX WITH MICELLES: EVIDENCE FOR INCREASED MOBILITY OF THE HELIX INVOLVVED IN THE ACTIVATION OF LIPOPROTEIN LIPASE.

Template:ABSTRACT PUBMED 12590574

Function

[APC2_HUMAN] Promotes rapid degradation of CTNNB1 and may function as a tumor suppressor. May function in Wnt signaling.^[1][2][3]

About this Structure

1o8t is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

• Zdunek J, Martinez GV, Schleucher J, Lycksell PO, Yin Y, Nilsson S, Shen Y, Olivecrona G, Wijmenga S. Global structure and dynamics of human apolipoprotein CII in complex with micelles: evidence for increased mobility of the helix involved in the activation of lipoprotein lipase. Biochemistry. 2003 Feb 25;42(7):1872-89. PMID:12590574 doi:http://dx.doi.org/10.1021/bi0267184

1. ↑ Nakagawa H, Murata Y, Koyama K, Fujiyama A, Miyoshi Y, Monden M, Akiyama T, Nakamura Y. Identification of a brain-specific APC homologue, APCL, and its interaction with beta-catenin. Cancer Res. 1998 Nov 15;58(22):5176-81. PMID:9823329
2. ↑ van Es JH, Kirkpatrick C, van de Wetering M, Molenaar M, Miles A, Kuipers J, Destree O, Peifer M, Clevers H. Identification of APC2, a homologue of the adenomatous polyposis coli tumour suppressor. Curr Biol. 1999 Jan 28;9(2):105-8. PMID:10021369
3. ↑ Jarrett CR, Blancato J, Cao T, Bressette DS, Cepeda M, Young PE, King CR, Byers SW. Human APC2 localization and allelic imbalance. Cancer Res. 2001 Nov 1;61(21):7978-84. PMID:11691822