2i5w

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Template:STRUCTURE 2i5w

Contents 1 Structure of hOGG1 crosslinked to DNA sampling a normal G adjacent to an oxoG 2 Disease 3 Function 4 About this Structure 5 See Also 6 Reference

Structure of hOGG1 crosslinked to DNA sampling a normal G adjacent to an oxoG

Template:ABSTRACT PUBMED 17015827

Disease

[OGG1_HUMAN] Defects in OGG1 may be a cause of renal cell carcinoma (RCC) [MIM:144700]. It is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma.

Function

[OGG1_HUMAN] DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.

About this Structure

2i5w is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

• DNA glycosylate

Reference

• Banerjee A, Verdine GL. A nucleobase lesion remodels the interaction of its normal neighbor in a DNA glycosylase complex. Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15020-5. Epub 2006 Oct 2. PMID:17015827