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1wnt

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Template:STRUCTURE 1wnt

Contents

Strucutre of the tetrameric form of Human L-Xylulose Reductase

Template:ABSTRACT PUBMED 15906319

Disease

[DCXR_HUMAN] Note=The enzyme defect in pentosuria has been shown to involve L-xylulose reductase. Essential pentosuria is an inborn error of metabolism characterized by the excessive urinary excretion of the pentose L-xylulose.

Function

[DCXR_HUMAN] Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules.

About this Structure

1wnt is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • El-Kabbani O, Carbone V, Darmanin C, Ishikura S, Hara A. Structure of the tetrameric form of human L-Xylulose reductase: probing the inhibitor-binding site with molecular modeling and site-directed mutagenesis. Proteins. 2005 Aug 15;60(3):424-32. PMID:15906319 doi:10.1002/prot.20487

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