1lgn

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Template:STRUCTURE 1lgn

Contents

DECAMERIC DAMP COMPLEX OF HUMAN SERUM AMYLOID P COMPONENT

Template:ABSTRACT PUBMED 9217261

Disease

[SAMP_HUMAN] Note=SAP is a precursor of amyloid component P which is found in basement membrane and associated with amyloid deposits.

Function

[SAMP_HUMAN] Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin.

About this Structure

1lgn is a 5 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Hohenester E, Hutchinson WL, Pepys MB, Wood SP. Crystal structure of a decameric complex of human serum amyloid P component with bound dAMP. J Mol Biol. 1997 Jun 20;269(4):570-8. PMID:9217261 doi:10.1006/jmbi.1997.1075

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