1ow0

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Template:STRUCTURE 1ow0

Contents

Crystal structure of human FcaRI bound to IgA1-Fc

Template:ABSTRACT PUBMED 12768205

Disease

[IGHA1_HUMAN] Note=A chromosomal aberration involving IGHA1 is found in multiple myeloma (MM) cell lines. Translocation t(1;14)(q21;q32) that forms a FCRL4-IGHA1 fusion protein.

Function

[IGHA1_HUMAN] Ig alpha is the major immunoglobulin class in body secretions. It may serve both to defend against local infection and to prevent access of foreign antigens to the general immunologic system. [FCAR_HUMAN] Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production.

About this Structure

1ow0 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  • Herr AB, Ballister ER, Bjorkman PJ. Insights into IgA-mediated immune responses from the crystal structures of human FcalphaRI and its complex with IgA1-Fc. Nature. 2003 Jun 5;423(6940):614-20. Epub 2003 May 21. PMID:12768205 doi:http://dx.doi.org/10.1038/nature01685

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