3h2u

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Template:STRUCTURE 3h2u

Contents

Human raver1 RRM1, RRM2, and RRM3 domains in complex with human vinculin tail domain Vt

Template:ABSTRACT PUBMED 19523901

Function

[RAVR1_HUMAN] Cooperates with PTBP1 to modulate regulated alternative splicing events. Promotes exon skipping. Cooperates with PTBP1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA (By similarity).

About this Structure

3h2u is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  • Lee JH, Rangarajan ES, Yogesha SD, Izard T. Raver1 interactions with vinculin and RNA suggest a feed-forward pathway in directing mRNA to focal adhesions. Structure. 2009 Jun 10;17(6):833-42. PMID:19523901 doi:S0969-2126(09)00193-2

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OCA

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