3gni
From Proteopedia
Contents |
Structure of STRAD and MO25
Template:ABSTRACT PUBMED 19513107
Disease
[STRAA_HUMAN] Note=A homozygous 7-kb deletion involving STRADA is a cause of a syndrome characterized by polyhydramnios, megalencephaly and symptomatic epilepsy.
Function
[CAB39_HUMAN] Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1. [STRAA_HUMAN] Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation.[1][2][3]
About this Structure
3gni is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Zeqiraj E, Filippi BM, Goldie S, Navratilova I, Boudeau J, Deak M, Alessi DR, van Aalten DM. ATP and MO25alpha regulate the conformational state of the STRADalpha pseudokinase and activation of the LKB1 tumour suppressor. PLoS Biol. 2009 Jun 9;7(6):e1000126. Epub 2009 Jun 9. PMID:19513107 doi:10.1371/journal.pbio.1000126
- ↑ Baas AF, Boudeau J, Sapkota GP, Smit L, Medema R, Morrice NA, Alessi DR, Clevers HC. Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD. EMBO J. 2003 Jun 16;22(12):3062-72. PMID:12805220 doi:10.1093/emboj/cdg292
- ↑ Boudeau J, Baas AF, Deak M, Morrice NA, Kieloch A, Schutkowski M, Prescott AR, Clevers HC, Alessi DR. MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm. EMBO J. 2003 Oct 1;22(19):5102-14. PMID:14517248 doi:10.1093/emboj/cdg490
- ↑ Zeqiraj E, Filippi BM, Deak M, Alessi DR, van Aalten DM. Structure of the LKB1-STRAD-MO25 Complex Reveals an Allosteric Mechanism of Kinase Activation. Science. 2009 Nov 5. PMID:19892943
Categories: Homo sapiens | Aalten, D M.F van. | Alessi, D R. | Goldie, S. | Zeqiraj, E. | Adaptor protein | Alpha helical repeat protein | Atp-binding | Cell cycle | Kinase | Kinase fold | Metal binding protein-transferase complex | Nucleotide-binding | Nucleus | Phosphoprotein | Pseudokinase | Signaling protein-signaling protein complex | Transferase