2lkj
From Proteopedia
Contents |
Structures and Interaction Analyses of the Integrin Alpha-M Beta-2 Cytoplasmic Tails
Template:ABSTRACT PUBMED 22052909
Disease
[ITAM_HUMAN] Genetic variations in ITGAM has been associated with susceptibility to systemic lupus erythematosus type 6 (SLEB6) [MIM:609939]. Systemic lupus erythematosus (SLE) is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.
Function
[ITAM_HUMAN] Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.
About this Structure
2lkj is a 1 chain structure. Full experimental information is available from OCA.
Reference
- Chua GL, Tang XY, Amalraj M, Tan SM, Bhattacharjya S. Structures and interaction analyses of the integrin alphaMbeta2 cytoplasmic tails. J Biol Chem. 2011 Nov 3. PMID:22052909 doi:10.1074/jbc.M111.280164
