2r42

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Template:STRUCTURE 2r42

Contents 1 The Biochemical and Structural Basis for feedback Inhibition of Mevalonate Kinase and Isoprenoid Metabolism 2 Disease 3 Function 4 About this Structure 5 Reference

The Biochemical and Structural Basis for feedback Inhibition of Mevalonate Kinase and Isoprenoid Metabolism

Template:ABSTRACT PUBMED 18302342

Disease

[KIME_RAT] Note=Mutation in the mevalonate kinase gene causes mevalonicaciduria.

Function

[KIME_RAT] May be a regulatory site in cholesterol biosynthetic pathway.

About this Structure

2r42 is a 1 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

• Fu Z, Voynova NE, Herdendorf TJ, Miziorko HM, Kim JJ. Biochemical and structural basis for feedback inhibition of mevalonate kinase and isoprenoid metabolism. Biochemistry. 2008 Mar 25;47(12):3715-24. Epub 2008 Feb 27. PMID:18302342 doi:10.1021/bi7024386