1i7e

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Template:STRUCTURE 1i7e

Contents

C-Terminal Domain Of Mouse Brain Tubby Protein bound to Phosphatidylinositol 4,5-bis-phosphate

Template:ABSTRACT PUBMED 11375483

Disease

[TUB_MOUSE] Note=Defects in Tub are the cause of maturity-onset obesity, insulin resistance and sensory deficits.

Function

[TUB_MOUSE] Functions in signal transduction from heterotrimeric G protein-coupled receptors. Binds to membranes containing phosphatidylinositol 4,5-bisphosphate. Can bind DNA (in vitro). May contribute to the regulation of transcription in the nucleus. Could be involved in the hypothalamic regulation of body weight. Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages (By similarity).[1][2]

About this Structure

1i7e is a 1 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

  • Santagata S, Boggon TJ, Baird CL, Gomez CA, Zhao J, Shan WS, Myszka DG, Shapiro L. G-protein signaling through tubby proteins. Science. 2001 Jun 15;292(5524):2041-50. Epub 2001 May 24. PMID:11375483 doi:10.1126/science.1061233
  1. ↑ Boggon TJ, Shan WS, Santagata S, Myers SC, Shapiro L. Implication of tubby proteins as transcription factors by structure-based functional analysis. Science. 1999 Dec 10;286(5447):2119-25. PMID:10591637
  2. ↑ Santagata S, Boggon TJ, Baird CL, Gomez CA, Zhao J, Shan WS, Myszka DG, Shapiro L. G-protein signaling through tubby proteins. Science. 2001 Jun 15;292(5524):2041-50. Epub 2001 May 24. PMID:11375483 doi:10.1126/science.1061233

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