1soh

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Template:STRUCTURE 1soh

Contents

The structure of human apolipoprotein C-II in dodecyl phosphocholine

Template:ABSTRACT PUBMED 15209504

Disease

[APOC2_HUMAN] Defects in APOC2 are the cause of hyperlipoproteinemia type 1B (HLPP1B) [MIM:207750]. It is an autosomal recessive trait characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis.[1]

Function

[APOC2_HUMAN] Component of the very low density lipoprotein (VLDL) fraction in plasma, and is an activator of several triacylglycerol lipases. The association of APOC2 with plasma chylomicrons, VLDL, and HDL is reversible, a function of the secretion and catabolism of triglyceride-rich lipoproteins, and changes rapidly.

About this Structure

1soh is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

  • MacRaild CA, Howlett GJ, Gooley PR. The structure and interactions of human apolipoprotein C-II in dodecyl phosphocholine. Biochemistry. 2004 Jun 29;43(25):8084-93. PMID:15209504 doi:10.1021/bi049817l
  1. ↑ Inadera H, Hibino A, Kobayashi J, Kanzaki T, Shirai K, Yukawa S, Saito Y, Yoshida S. A missense mutation (Trp 26-->Arg) in exon 3 of the apolipoprotein CII gene in a patient with apolipoprotein CII deficiency (apo CII-Wakayama). Biochem Biophys Res Commun. 1993 Jun 30;193(3):1174-83. PMID:8323539 doi:http://dx.doi.org/S0006-291X(83)71749-3

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