1b66

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Template:STRUCTURE 1b66

Contents

6-PYRUVOYL TETRAHYDROPTERIN SYNTHASE

Template:ABSTRACT PUBMED 10024455

Disease

[PTPS_RAT] Note=Deficiency leads to phenylketonuria.

Function

[PTPS_RAT] Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin.

About this Structure

1b66 is a 2 chain structure with sequence from Rattus rattus. Full crystallographic information is available from OCA.

Reference

  • Ploom T, Thony B, Yim J, Lee S, Nar H, Leimbacher W, Richardson J, Huber R, Auerbach G. Crystallographic and kinetic investigations on the mechanism of 6-pyruvoyl tetrahydropterin synthase. J Mol Biol. 1999 Feb 26;286(3):851-60. PMID:10024455 doi:10.1006/jmbi.1998.2511
  • Colloc'h N, Poupon A, Mornon JP. Sequence and structural features of the T-fold, an original tunnelling building unit. Proteins. 2000 May 1;39(2):142-54. PMID:10737935

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